EMBO Member
Leila Akkari
EMBO 2026
Former EMBO Young Investigator (2021)
Netherlands Cancer Institute, Amsterdam, Netherlands
Macrophage dynamics in cancer progression
Our group studies the microenvironment-mediated mechanisms of tumor maintenance, therapeutic resistance and recurrence in brain and liver malignancies, in order to to identify exploitable therapeutic vulnerabilities in macrophage heterogeneous subsets. Using mouse models of glioma and hepatocellular carcinoma combined with lineage tracing systems, we explore and target the functions of resident versus infiltrating macrophages.
Keywords
Tumor microenvironement / macrophages / therapy resistance / cancer immunity / brain tumor / liver cancer / metabolic rewiring