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EMBO Young Investigator

Leila Akkari

Netherlands Cancer Institute, Amsterdam | Netherlands

YIP 2021–2026

Macrophage dynamics in cancer progression

Our group studies the microenvironment-mediated mechanisms of tumor maintenance, therapeutic resistance and recurrence in brain and liver malignancies, in order to to identify exploitable therapeutic vulnerabilities in macrophage heterogeneous subsets. Using mouse models of glioma and hepatocellular carcinoma combined with lineage tracing systems, we explore and target the functions of resident versus infiltrating macrophages.

Keywords: Tumor microenvironement / macrophages / therapy resistance / cancer immunity / brain tumor / liver cancer / metabolic rewiring

Subject area(s): Cellular Metabolism | Cell & Tissue Architecture | Immunology | Molecular Medicine | Systems Biology