EMBO Young Investigator
Duke-NUS Medical School, Singapore | Singapore
Our genome encodes thousands of microproteins, many of which regulate metabolism in the mitochondria. We have developed traditional and high-throughput methods to find and de-orphanize these microproteins, thereby providing novel insights into how mitochondria achieve optimal function when metabolically challenged. We aim to understand the evolutionary origins and production of these microproteins and, most importantly, how they can be targeted to ameliorate mitochondrial dysfunction.
Keywords: sORFs / smORFs / SEP / microprotein / mitochondria / electron transport chain / inflammasomes / inflammation
Subject area(s): Immunology | Cellular Metabolism