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EMBO Young Investigator

Lena Ho

Duke-NUS Medical School, Singapore | Singapore

YIP 2022–2025

Microproteins in metabolism and inflammation

Our genome encodes thousands of microproteins, many of which regulate metabolism in the mitochondria. We have developed traditional and high-throughput methods to find and de-orphanize these microproteins, thereby providing novel insights into how mitochondria achieve optimal function when metabolically challenged. We aim to understand the evolutionary origins and production of these microproteins and, most importantly, how they can be targeted to ameliorate mitochondrial dysfunction.

Keywords: sORFs / smORFs / SEP / microprotein / mitochondria / electron transport chain / inflammasomes / inflammation

Subject area(s): Cellular Metabolism | Immunology