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EMBO Member

Leoš Shivaya Valášek

Academy of Sciences of the Czech Republic, Prague | Czech Republic

EMBO 2024

Translation control and tRNA biology

My lab investigates the basics of protein synthesis and its regulation under stress, both at the general as well as gene-specific levels. Our research focuses on understanding how ribosomes recognize where to start and stop translation. We are also interested in tRNAs promoting stop codon readthrough and various alternative genetic codes, the detailed knowledge of which could be used in the treatment of various genetic diseases.

Keywords: Gene regulation / translation / translation initiation / translation termination / reinitiation / stop codon readthrough / ribosome / initiation factor / termination factor / tRNA / genetic codes

Subject area(s): RNA | Proteins & Biochemistry