Search    Show all

1 People found

filters applied:


1 / 1

EMBO Associate Member

Leonard I. Zon

Children's Hospital, Boston | United States

EMBO 2021

Developmental biology of hematopoiesis

My lab focuses on zebrafish as a model for blood diseases and cancer. We use genetic screens to find mutants with defective blood development and discovered five new human diseases as a result. We use chemical genetics to find small molecules that accelerate blood stem cell development or engraftment. Several compounds are being tested in humans. We have developed several cancer models in the zebrafish including transgenic and gene targeted fish.

Keywords: Blood cell regeneration / developmental hematopoiesis / zebrafish disease models / stem cell niche / hematology / cancer

Subject area(s): Chromatin & Transcription | Differentiation & Death | Immunology | Molecular Medicine