EMBO Member
Leonid A. Sazanov
EMBO 2018
Institute of Science and Technology Austria (IST), Klosterneuburg, Austria
Structure and function of membrane proteins
We are interested in the structural biology of large membrane protein complexes. We have solved by X-ray crystallography the first atomic structure of the bacterial complex I (~550 kDa, 16 subunits, 9 Fe-S clusters, 64 TM helices). We also solved by cryo-EM the first complete atomic structure of the more elaborate mammalian complex I (~ 1 MDa, 45 subunits, 78 TM helices), as well as determined the architecture of respiratory supercomplexes.
Keywords
Membrane protein structure / respiratory chain / mitochondria / complex I / respiratory supercomplexes / bioenergetics / X-ray crystallography / cryo-EM