Epi-alterations in breast cancer brain metastasis
My research focuses on epigenetics and epitranscriptomics in the context of tumour plasticity in breast cancer brain metastasis. While DNA mutations play a significant role in the development of aggressive cancer, the contribution of epigenomics and epitranscriptomics is rapidly gaining recognition. Our work exploits the highly dynamic nature of breast cancer brain metastasis, to develop radical new strategies to treat this underserved patient population.
Keywords
Breast cancer / brain metastasis / estrogen receptor / genomic profiling / transcriptomics / epi-genomics / epi-tRNAscriptomics