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EMBO Associate Member

Lewis C. Cantley

United States

EMBO 2015

Cancer metabolism and phosphoinositide signaling

The Cantley lab employs a wide range of techniques in its investigation of cancer metabolism and phosphoinositide signaling. From genetically engineered mouse model systems and human cancer cell lines to metabolomic, transcriptomic and proteomic analyses, to the biochemical characterization of enzymes, we use a variety of tools and an interdisciplinary approach to paint a more complete picture of cancer and develop therapies based on novel enzyme targets and other promising new approaches. [ from ]

Keywords: PI3-kinase signalling / cancer cell metabolism / insulin signalling / drug development / phosphoinositides / protein kinase pathways

Subject area(s): Cellular Metabolism | Molecular Medicine | Signal Transduction