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EMBO Member

Lluis Quintana-Murci

Institut Pasteur, Paris | France

EMBO 2014

Human genome diversity and adaptation to pathogens

Our lab is focused on understanding how natural selection and demographic processes have shaped the patterns of diversity of the human genome. We explore how pathogens have exerted pressure on host genes to unmask critical immunological mechanisms in infectious disease resistance. To this end, we combine population genetics and cellular genomics approaches, with computational modelling and development of new statistical frameworks.

Keywords: Population genetics / human evolution / innate immunity / infectious disease / cellular genomics

Subject area(s): Genomic & Computational Biology | Immunology | Evolution & Ecology