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EMBO Member

Lori A. Passmore

MRC LMB, Cambridge | United Kingdom

EMBO 2018 | MemC 20–23 | MemC 24–26

Protein complexes that regulate mRNA polyA tails

My lab aims to understand the molecular mechanisms of multi-protein complexes, with an emphasis on the macromolecular machines that add or remove mRNA polyA tails. We are establishing how polyA tail position and length are determined by the activities of Cleavage and Polyadenylation Factor (CPF), Pan2–Pan3 and Ccr4–Not. We also develop new methods in electron cryo-microscopy (cryo-EM) to study these complexes.

Keywords: Gene expression / RNA / protein structure / cryo-EM / polyadenylation

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics