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EMBO Young Investigator

Luca Giorgetti

Friedrich Miescher Institute, Basel | Switzerland

YIP 2018

Chromosome structure and transcription

Our group studies the relationship between chromosome structure and transcriptional regulation in mammalian cells. We aim to understand how enhancers control transcription of their target genes from large genomic distances, in the context of the three-dimensional structure of chromosomes and its dynamics. To this aim, we use an integrated approach combining genomics, genetic engineering, single-cell experiments and physical modelling.

Keywords: Chromosome structure / transcriptional regulation / epigenetics / physical modeling / genomics

Subject area(s): Chromatin & Transcription | Genomic & Computational Biology