Gene transcription in development and diseases
The research effort of my group is focused on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation. More recently, the Di Croce lab has become interested in understanding how variations in the assembly of Polycomb complexes occur and influence mouse ES cell differentiation and animal development.
Keywords
Chromatin / gene regulation / epigenetics / stem cells / cancer