Glycosphingolipids in trafficking and delivery
Our research aims at establishing fundamental concepts of endocytosis and intracellular trafficking. We have discovered retrograde trafficking between early endosomes and the Golgi apparatus, and demonstrated that protein-induced glycosphingolipid clustering acts as a driving force for membrane invagination in clathrin-independent endocytosis. We are also exploiting these discoveries for the development of innovative cancer therapy strategies.
Keywords
Endocytosis / retrograde transport / protein toxins / glycosphingolipids / membrane compartmentalization