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EMBO Member

Ludger Johannes

Institut Curie, Paris | France

EMBO 2012

Glycosphingolipids in trafficking and delivery

Our research aims at establishing fundamental concepts of endocytosis and intracellular trafficking. We have discovered retrograde trafficking between early endosomes and the Golgi apparatus, and demonstrated that protein-induced glycosphingolipid clustering acts as a driving force for membrane invagination in clathrin-independent endocytosis. We are also exploiting these discoveries for the development of innovative cancer therapy strategies.

Keywords: Endocytosis / retrograde transport / protein toxins / glycosphingolipids / membrane compartmentalization

Subject area(s): Membranes & Transport | Microbiology, Virology & Pathogens | Molecular Medicine