University, Utrecht | Netherlands
We study the mechanisms by which cells establish and maintain their precise shape and intracellular organization. We particularly focus on the microtubule cytoskeleton of neurons, whose complex spatial architecture and polarized organization into axons and dendrites are crucial for proper functioning. To understand how microtubule organization underlies (polarized) transport, we develop and apply multiple forms of advanced (super-resolution) light microscopy.
Keywords: Intracellular transport / motor proteins / cytoskeleton / neurons / cell polarity / super-resolution microscopy / optogenetics