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EMBO Member

Lumír Krejči

Masaryk University, Brno | Czech Republic

EMBO 2024

DNA recombination, replication and genome stability

My group focuses on the role of homologous recombination (HR) in preserving genome stability. We investigate how HR factors facilitate double-strand break repair and safeguard stalled replication forks, and how failures in these processes contribute to genome instability and disease development. Additionally, we are actively developing selective nuclease inhibitors, determining their mechanisms, and identifying potential therapeutic applications.

Keywords: DNA recombination / DNA replication / DNA repair / DDR inhibition / genome stability

Subject area(s): Structural Biology & Biophysics | Proteins & Biochemistry | Genome Stability & Dynamics