EMBO Member
Université Paul Sabatier (3), Toulouse | France
EMBO 2022
Our lab revealed, through cellular and biophysical studies (1) that apoptotic cells, far from being passively eliminated, actively participate in morphogenesis, through the formation of a contractile actomyosin structure that links the apical surface to the apoptotic nucleus, thus ensuring apoptotic force propagation; and (2) that cells undergoing EMT, generate a surprisingly similar apico-basal force, and contribute mechanically to morphogenesis.
Keywords: Biomechanics of epithelia / morphogenesis / apoptosis / epithelio-mesenchymal transition / in-silico modeling
Subject area(s): Cell & Tissue Architecture | Development | Differentiation & Death | Structural Biology & Biophysics