EMBO Member
Magdalini Polymenidou
EMBO 2025
Former EMBO Young Investigator (2018)
University, Zurich, Switzerland
Molecular pathogenesis of neurodegeneration
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases, characterized by accumulation of RNA-binding proteins such as TDP-43 and FUS, and dipeptide repeat proteins. Our lab combines protein biochemistry, RNA analysis and cellular assays to understand the molecular mechanisms that trigger protein aggregation in ALS/FTD, the basis of disease heterogeneity and the mechanisms of neurotoxicity.
Keywords
Neurodegeneration / ALS / FTD / RNA-binding proteins / TDP-43 / FUS / DPRs / phase separation / protein aggregation / prion-like