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EMBO Young Investigator

Magdalini Polymenidou

University, Zurich | Switzerland

YIP 2018

Molecular pathogenesis of neurodegeneration

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases, characterized by accumulation of RNA-binding proteins such as TDP-43 and FUS, and dipeptide repeat proteins. To understand the molecular mechanisms that trigger protein aggregation in ALS/FTD, the basis of disease heterogeneity and the mechanisms of neurotoxicity, our lab combines protein biochemistry, RNA analysis and cellular assays.

Keywords: Neurodegeneration / ALS / FTD / RNA-binding proteins / TDP-43 / FUS / DPRs / phase separation / protein aggregation / prion-like

Subject area(s): Molecular Medicine | Neuroscience | Proteins & Biochemistry