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EMBO Member

Maike Sander

MDC, Berlin | Germany

EMBO 2025

Understanding beta cell failure in diabetes

Our research aims to uncover the molecular mechanisms that govern the formation and function of insulin-producing pancreatic beta cells, with the goal of developing novel therapies for diabetes. We integrate genetic approaches in human stem cell-derived organoids with single-cell genomics and genetic data to map gene regulatory programs in islet cells in health and disease.

Keywords: Diabetes / pancreatic islet / islet cell development / beta cell function / gene regulation / cellular metabolism / organoids / human iPSC

Subject area(s): Chromatin & Transcription | Development | Molecular Medicine

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