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EMBO Member

Manuel Espinosa

Centro de Investigaciones Biológicas (CIB / CSIC), Madrid | Spain

EMBO 1996 | YipC 07–10 | FelC 08–12

Bacterial gene expression and gene transfer

We work on horizontal gene transfer using plasmid pMV158 as model. It is the prototype of the MOBV family of mobilization proteins. We also work on chromatically-encoded pneumococcal toxin-antitoxin operons. We focus on protein-DNA interactions, control of gene expression, structure of replication and relaxation proteins, and mechanisms of lateral gene spread and identification of novel pneumococcal virulence genes.

Keywords: Plasmid biology / control of prokaryotic gene expression / molecular microbiology of pathogenic bacteria / plasmid mobility & transfer

Subject area(s): Genome Stability & Dynamics | Microbiology, Virology & Pathogens | Proteins & Biochemistry