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EMBO Young Investigator

Manuel Irimia

Centro de Regulación Genómica (CRG), Barcelona | Spain

YIP 2018

Transcriptomics of development and evolution

My lab is interested in understanding the roles that transcriptomic diversification, especially through alternative splicing, play in vertebrate development and evolution. A major topic of our current research are microexons: tiny exons that are switched on during neuronal differentiation, sculpt protein surfaces, are misregulated in the brains of autistic patients, and have a fascinating evolutionary history.

Keywords: Evolution / transcriptomics / alternative splicing / evo-devo / neurodevelopment

Subject area(s): Evolution & Ecology | RNA | Neuroscience | Genomic & Computational Biology | Development