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EMBO Member

Manuela Baccarini

University, Vienna | Austria

EMBO 2012 | GinC 19–22

Deciphering the MAPK pathway in vivo

The Ras/Raf/MEK/ERK pathway represents the oldest paradigm of a cytosolic signal transduction cascade. My group focuses on deciphering the functions of Raf and MEK in the context of the whole organism, and on determining how the MAPK pathway is wired in vivo, during development as well as in postnatal life, in particular in the context of tumorigenesis.

Keywords: MAPK cascade / mouse models / pathway cross-talk / development / tumorigenesis

Subject area(s): Differentiation & Death | Molecular Medicine | Signal Transduction