Deciphering the MAPK pathway in vivo
The Ras/Raf/MEK/ERK pathway represents the oldest paradigm of a cytosolic signal transduction cascade. My group focuses on deciphering the functions of Raf and MEK in the context of the whole organism, and on determining how the MAPK pathway is wired in vivo, during development as well as in postnatal life, in particular in the context of tumorigenesis.
Keywords
MAPK cascade / mouse models / pathway cross-talk / development / tumorigenesis