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EMBO Member

Marcel Méchali

Institut de Génétique Humaine, Montpellier | France

EMBO 2002

DNA Replication and Genome Dynamics

Our main goal is to unravel the nature of DNA replication origins in multicellular eukaryotes. We identified an Origin G-rich Repeated Element (OGRE) that could form G quadruplexes, orientated 150-300 bp upstream of the initiation site in a nucleosome-free region. We also demonstrated its functional importance. We also revealed a specific organisation of origins along TAD domains, which is disorganised in cancer cells.

Keywords: DNA replication / epigenetics / chromatin / nuclear organization / development

Subject area(s): Cell Cycle | Chromatin & Transcription | Genome Stability & Dynamics | Genomic & Computational Biology