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EMBO Member

Marek Basler

Biozentrum, Basel | Switzerland

EMBO 2023

Function of bacterial Type VI secretion systems

My lab studies structure, function and dynamics of the Type VI secretion system (T6SS). This nanomachine is evolutionarily related to contractile phage tails and delivers proteins into both bacterial and eukaryotic cells. We use various biochemical, genetic and imaging techniques to understand the key molecular mechanisms underlying the assembly, substrate delivery, and regulation of T6SS function during bacterial cell-cell interactions.

Keywords: Bacterial secretion systems / cell-cell interactions / advanced microscopy / protein localization and dynamics / signalling cascades

Subject area(s): Membranes & Transport | Microbiology, Virology & Pathogens | Proteins & Biochemistry | Structural Biology & Biophysics