EMBO Member
Marek Basler
EMBO 2023
Former EMBO Young Investigator (2016)
Biozentrum, Basel, Switzerland
Function of bacterial Type VI secretion systems
My lab studies structure, function and dynamics of the Type VI secretion system (T6SS). This nanomachine is evolutionarily related to contractile phage tails and delivers proteins into both bacterial and eukaryotic cells. We use various biochemical, genetic and imaging techniques to understand the key molecular mechanisms underlying the assembly, substrate delivery, and regulation of T6SS function during bacterial cell-cell interactions.
Keywords
Bacterial secretion systems / cell-cell interactions / advanced microscopy / protein localization and dynamics / signalling cascades