University, Lisbon | Portugal
My lab has its major focus on the molecular and cellular mechanisms of biogenesis, traffic and degradation of wt and mutant protein CFTR, which when mutated causes the genetic disease Cystic Fibrosis (CF). To understand CF mechanisms globally we use transcriptomics, proteomics and functional genomics (functional siRNA screens). Our results translate into the clinic for better CF diagnosis, prognosis and personalized therapies.
Keywords: Endoplasmic reticulum quality control / protein (mis)folding and disease / secretory traffic / functional genomics / cystic fibrosis