Centro Andaluz de Biología del Desarrollo (CABD), Sevilla | Spain
EMBO 2020 | FelC 21–24
Our laboratory tries to decipher the molecular and cellular mechanisms by which counteracting forces exerted by cell-extracellular matrix interactions and actomyosin contractility regulate cell migration and cell shape during morphogenesis. We use Drosophila as our model system, and a multidisciplinary approach combining genetics, transcriptomic analysis, cell and molecular biology, 4D imaging, biophysical measurements and mathematical modelling.
Keywords: Integrin mediated cell-ECM interactions / laminins / morphogenesis / cell shape / cell migration / actomyosin dynamics / DrosAfrica
Subject area(s): Structural Biology & Biophysics | Development | Cell & Tissue Architecture