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EMBO Member

Maria Dolores Martin-Bermudo

Centro Andaluz de Biología del Desarrollo (CABD), Sevilla | Spain

EMBO 2020 | FelC 21–24

Cell-ECM and actomyosin forces in morphogenesis

Our laboratory tries to decipher the molecular and cellular mechanisms by which counteracting forces exerted by cell-extracellular matrix interactions and actomyosin contractility regulate cell migration and cell shape during morphogenesis. We use Drosophila as our model system, and a multidisciplinary approach combining genetics, transcriptomic analysis, cell and molecular biology, 4D imaging, biophysical measurements and mathematical modelling.

Keywords: Integrin mediated cell-ECM interactions / laminins / morphogenesis / cell shape / cell migration / actomyosin dynamics / DrosAfrica

Subject area(s): Cell & Tissue Architecture | Development | Structural Biology & Biophysics