Human mitochondrial DNA maintenance
My laboratory studies DNA maintenance in mammalian mitochondria. We use in-vitro biochemistry, structural biology, and cell biology to explore the underlying enzymatic processes. We also investigate the molecular consequences of disease-causing mutations affecting mitochondrial DNA replication and work on developing new, rational therapeutic approaches.
Keywords
Mitochondria / DNA replication / transcription / mitochondrial DNA synthesis / S7 noncoding RNA