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EMBO Global Investigator

Maria-Isabel Yuseff

Pontifical Catholic University of Chile, Santiago de Chile | Chile

GIN 2020–2024

Cell biological control of B cell responses

My lab combines cell biology and immunology to unravel how membrane trafficking, cytoskeleton remodeling and proteostasis control B cell activation. By using quantitative imaging approaches, we study the ability of B cells to sense, acquire and present antigens. Our goal is to understand how these functions are fine-tuned by external cues imposed by the physical properties of the environment as well as by inflammation.

Keywords: Immune synapse / cytoskeleton / proteasome / membrane trafficking / lysosome secretion

Subject area(s): Cell & Tissue Architecture | Immunology | Membranes & Transport | Signal Transduction