EMBO Member
Maria Sibilia
EMBO 2012 | YipC 13–16 | FelC 19–22
Institute of Cancer Research, Medical University of Vienna, Austria
EGFR & Innate Immune Signaling in Cancer
We employ genetically engineered mouse models to investigate the molecular mechanism governing malignant transformation, focusing on EGF-receptor signaling pathways. We are particularly interested in tumor-stroma interactions with emphasis on how innate immune cells affect tumor growth. Recent efforts are also exploring novel immunomodulatory concepts to enhance immunity against tumors.
Keywords
Mouse genetics / EGFR signaling / tumor biology and microenvironment / inflammation / tumor immunology