MRC LMB, Cambridge | United Kingdom
EMBO 1989 | Council 95–00 | MemPubC 96–01
Our aim is to understand the molecular and cell-biological mechanisms underlying the transduction of the Wnt signal from the plasma membrane to the nucleus in normal and malignant cells. In focus are the molecular functions of positive regulators of the Wnt pathway that have potential as drug targets, including Dishevelled and the Pygo-BCL9 complex. We are also interested in the regulation of Wnt signalling components by the ubiquitin system.
Keywords: Wnt signalling / transcriptional control / ubiquitin / cancer