Gif-sur-Yvette | France
I use bulk solution and single filament kinetics and thermodynamic analysis of actin filament assembly in vitro to understand the molecular mechanisms by which polarized actin assembly is regulated in motility. I characterize the function of all main regulators of actin assembly. My goal is to challenge the derived mechanistic insight to reconstitute motile processes in vitro with a minimal number of pure components.
Keywords: Cytoskeleton dynamics / cell motility / actin self-assembly / actin regulatory proteins / Arp2/3 complex / formins
Subject area(s): Cell & Tissue Architecture | Proteins & Biochemistry | Structural Biology & Biophysics