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EMBO Member

Marie-Hélène Verlhac

Collège de France, Paris | France

EMBO 2018

Oocyte mechanics and morphogenesis

The asymmetry in size of divisions in oocytes has been conserved through evolution and permits maternal stores to be retained in the oocyte for further embryo development. Using genetics, two-hybrid screening, live imaging combined with bio-physics, my lab has been precursor in the study of acentrosomal meiotic spindle assembly and positioning in mouse oocytes, both processes which are essential for the success of these asymmetric divisions.

Keywords: Meiosis / actin cytoskeleton / chromosome segregation / oocyte biology / spindle assembly checkpoint

Subject area(s): Cell Cycle | Cell & Tissue Architecture | Development | Genome Stability & Dynamics