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EMBO Member

Marina Mapelli

European Institute of Oncology (IEO), Milano | Italy

EMBO 2022

Mechanisms of oriented divisions and self-renewal

Our group is interested in the mechanisms of oriented cell division and stem cell fate determination. Specifically, we study macromolecular assemblies coordinating division orientation with epithelial polarity, which allow self-renewal and tissue homeostasis. For this, we combine high-resolution structural biology, biochemistry and cell biology. Recently we became interested in understanding the mechanistic basis of stem cell-niche communication.

Keywords: Oriented divisions / asymmetric divisions / self-renewal / mitosis / cell fate determination

Subject area(s): Cell Cycle | Cell & Tissue Architecture | Proteins & Biochemistry | Structural Biology & Biophysics