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EMBO Member

Markus Wahl

Freie Universität Berlin | Germany

EMBO 2014 | MemC 16–19

Mechanisms of molecular ribonucleoprotein machines

My group uses macromolecular crystallography, single-particle cryo-electron microscopy and analytical Biochemistry/Biophysics in combination with in vitro and in vivo functional assays to elucidate the molecular mechanisms, by which RNAs and proteins cooperate in molecular ribonucleoprotein (RNP) machineries. Our focus is on the regulation of bacterial transcription, pre-mRNA splicing and selected RNP remodeling enzymes.

Keywords: Biomacromolecular structure / gene regulation / pre-mRNA splicing / regulation of bacterial transcription / bacterial RNA polymerase / RNA-protein interactions / spliceosome

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics