Freie Universität Berlin | Germany
EMBO 2014 | MemC 16–19
My group investigates molecular mechanisms by which proteins and RNAs cooperate to bring about the biological functions of molecular ribonucleoprotein (RNP) machines. We conduct ultra-structural analyses of ribonucleoprotein complexes and their components, predominantly by using X-ray crystallography, and perform structure-guided functional investigations. We also develop small molecules that modulate RNP activities.
Keywords: Biomacromolecular structure / gene regulation / pre-mRNA splicing / regulation of bacterial transcription / bacterial RNA polymerase / RNA-protein interactions / spliceosome / X-ray crystallography