EMBO Member

Mart Loog

Tartu | Estonia

EMBO 2025

A unified model of Cdk substrate phosphorylation

We study cell cycle regulation by cyclin-dependent kinases (Cdk), multisite phosphorylation and substrate docking. We have proposed a 'unified model of Cdk substrate phosphorylation'. The timing of Cdk-driven processes is determined by a complex blend of tunable parameters, including the sequence, affinities, and positioning of docking sites. Variations of these parameters allow Cdk switches to be triggered at specific Cdk thresholds.

Keywords: Cell cycle / CDK / short linear motifs (SLiMs) / substrate docking / multisite phosphorylation / cell signalling networks / synthetic biology / bioengineering

Subject area(s): Cell Cycle | Proteins & Biochemistry | Signal Transduction

Links: orcid.org/0000-0003-1330-8453