A unified model of Cdk substrate phosphorylation
We study cell cycle regulation by cyclin-dependent kinases (Cdk), multisite phosphorylation and substrate docking. We have proposed a 'unified model of Cdk substrate phosphorylation'. The timing of Cdk-driven processes is determined by a complex blend of tunable parameters, including the sequence, affinities, and positioning of docking sites. Variations of these parameters allow Cdk switches to be triggered at specific Cdk thresholds.
Keywords
Cell cycle / CDK / short linear motifs (SLiMs) / substrate docking / multisite phosphorylation / cell signalling networks / synthetic biology / bioengineering