MPI für Biophysik, Frankfurt | Germany
Functional cellular modules have often been characterised in vitro. However, relatively little is known about their interplay and spatio-temporal arrangement in the context of living cells, i.e. their 'molecular sociology'. We use integrative, in-situ structural biology techniques to study the structure, function and assembly of very large macromolecular complexes in their native environment.
Keywords: Nuclear pore complexes / protein complex biogenesis / in-situ structural biology / mass spectrometry / imaging / cryo electron tomography