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EMBO Member

Martin Fussenegger

ETH Zurich, Basel | Switzerland

EMBO 2017

Engineering cells for therapeutic applications

We are passionate about using synthetic biology-inspired engineering strategies to program mammalian cells for therapeutic applications, such as biopharmaceutical manufacturing, drug discovery and cell-based therapies. Molecular prostheses, therapeutic gene circuits that enable implanted designer cells to monitor disease metabolites and process a dynamic closed-loop therapeutic response to prevent or correct the disease, remain a major focus.

Keywords: Synthetic biology / metabolic disorders / metabolic engineering / bioengineering / cell engineering / biotechnology / gene switches / gene circuits

Subject area(s): Cellular Metabolism | Differentiation & Death | Molecular Medicine | Systems Biology