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EMBO Young Investigator

Martin Guilliams

VIB - Flanders Institute for Biotechnology, Ghent | Belgium

YIP 2020–2024

Myeloid cells in liver homeostasis & regeneration

Our research focuses on the functional specialization of liver macrophages and on the cell-cell interactions with their niche, constituted of hepatocytes, stellate cells and endothelial cells. We are particularly interested in: (i) identifying the transcription factors that imprint the liver-specific identity, (ii) identifying the cell-cell circuits that maintain homeostasis and (iii) understanding the mechanisms that instruct liver regeneration.

Keywords: Macrophage / Kupffer cell / niche / development / tissue-imprinting / regeneration / liver

Subject area(s): Cell & Tissue Architecture | Development | Immunology