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EMBO Member

Martin Howard

John Innes Centre, Norwich | United Kingdom

EMBO 2024

Mathematical modelling in molecular biology

My group uses mathematical and biophysical modelling approaches to unravel molecular biology mechanisms that are too complex to dissect by intuition-driven experiments alone. I have used these approaches in two broad areas: epigenetic memory and cellular self-organization, working in long-term collaborations with experimentalists. Current research topics include Polycomb-based epigenetic memory, DNA methylation dynamics and meiotic crossover patterning.

Keywords: Mathematical modelling / biological physics / stochastic processes / epigenetic memory / Polycomb / temperature sensing / cell size control / meiotic crossover dynamics

Subject area(s): Systems Biology | Structural Biology & Biophysics | Genomic & Computational Biology