Free text search

---

EMBO Member

EMBO Associate Member

EMBO Young Investigator

EMBO Global Investigator

Male

Female

---

location no location selectedAustriaBelgiumCroatiaCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHungaryIcelandIrelandIsraelItalyLithuaniaLuxembourgNetherlandsNorwayPolandPortugalSlovakiaSloveniaSpainSwedenSwitzerlandTürkiyeUnited KingdomChileIndiaSingaporeRussian FederationArgentinaAustraliaBrazilCanadaChinaHong KongJapanKorea, Republic ofMexicoNew CaledoniaSaudi ArabiaSénégalTaiwanUnited StatesUruguay

---

subject area no subject area selectedCell & Tissue ArchitectureCell CycleCellular MetabolismChromatin & TranscriptionDevelopmentDifferentiation & DeathEvolution & EcologyGenome Stability & DynamicsGenomic & Computational BiologyImmunologyMembranes & TransportMicrobiology, Virology & PathogensMolecular MedicineNeurosciencePlant BiologyProteins & BiochemistryRNASignal TransductionStructural Biology & BiophysicsSystems Biology

---

EMBOwords

Select a subject area to display EMBOword sets here

EMBO Member

Martin W. Hetzer

Institute of Science and Technology Austria (IST), Klosterneuburg | Austria

EMBO 2024

Protein homeostasis and aging

Long-lived cells such as neurons fail to work properly as they age. Our group studies how cell maintenance and repair mechanisms function in non-dividing cells during adulthood and disease development, with implications in neurodegenerative diseases such as Alzheimer's. Our goal is to delay age-related decline by investigating how long-lived proteins (LLPs) exhibit little to no turnover in the brain and other organs with limited cell renewal.

Keywords: Long-lived proteins / nuclear pore complex / micronuclei / aging / age mosaicism

Subject area(s): Chromatin & Transcription | Development | Membranes & Transport | Proteins & Biochemistry