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EMBO Member

Massimiliano Mazzone

KU Leuven | Belgium

EMBO 2021

Immune cell fitness in cancer and inflammation

Our mission is to study how hypoxia, metabolic competition, and nutrient deprivation and availability, modulate the cellular composition and function within the tumor-microenvironment (TME). Focusing on cross-talks and molecular interplays within the TME, we aim to re-shape the immune system, blood vessels, and lymphatics. Starting from cancer, we extend our results to several inflammatory disorders (muscle and heart diseases, infections, etc.)

Keywords: Tumor microenvironment / macrophages / immunity / angiogenesis / hypoxia / metabolism / metastasis / cardiovascular diseases

Subject area(s): Cellular Metabolism | Cell & Tissue Architecture | Immunology | Molecular Medicine