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EMBO Member

Matthias H. Tschöp

Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit, Neuherberg-Oberschleissheim | Germany

EMBO 2020

Targeting of key mechanisms of the gut-brain axis

Our lab studies mechanisms of gut-brain communication enabling development of novel classes of drug candidates to prevent or reverse diabetes, obesity and metabolic diseases. These gut hormone polyagonist drugs are hybrid molecules of different peptide sequences that in some cases are coupled to small molecules. They show anti-obesity and anti-diabetic effects in animals and show promise in early clinical studies, due to their superior efficacy.

Keywords: Ghrelin / obesity / diabetes / metabolic disease / peptides / polyagonists

Subject area(s): Cellular Metabolism | Molecular Medicine | Signal Transduction