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EMBO Member

Matthias P. Lutolf

EPFL, Lausanne | Switzerland

EMBO 2018

Engineering stem cell self-organization

By uniquely interfacing bioengineering and stem cell biology, we study how stem cells take decisions and how their decision-making process is influenced by signals from the microenvironment. A major focus is on coaxing stem cells in vitro into organoids by exposing them to well-controlled artificial microenvironments. Our ambition is to achieve organoid development in a deterministic and predictable manner by steering stem cell self-organization.

Keywords: Bioengineering / stem cells / biomaterials / developmental biology / synthetic biology / organoids / self-organization

Subject area(s): Cell & Tissue Architecture | Development | Differentiation & Death | Systems Biology