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Maurizio Gatti

Università 'La Sapienza', Roma | Italy

EMBO 2011

Chromosome organization and cell division in Drosophila

We are using Drosophila melanogaster as model system to investigate two basic problems in cell biology. We are analyzing the structure and the DNA binding activity of terminin, a Drosophila telomere-capping complex that is functionally analogous to human shelterin. In addition, we are dissecting the mechanisms of Drosophila spindle assembly, focusing on the factors that control kinetochore-driven microtubule growth.

Keywords: Telomere capping / spindle assembly / centrosomes / cytokinesis / Drosophila

Subject area(s): Cell Cycle | Genome Stability & Dynamics