B cell memory in barrier tissues
One of the main features of our immune system is the ability to remember previously-encountered microbes. In our lab, we study how this memory is established in barrier tissues upon infection. In particular, we study tissue-resident memory B cells, which can rapidly produce antibody-secreting cells upon encounter of pathogens in the lung/gut mucosa. Targeting these cells is a promising approach to protect against airborne or enteric pathogens.
Keywords
B cells / IgA / fate decision / long-lived plasma cells / memory B cells