Human life starts with the fertilization of an egg. Depending on the age of the woman, around 10-50% of human eggs are chromosomally abnormal. The objective of our laboratory is to analyze causes of chromosomal abnormalities and the maternal age effect in mammalian eggs, including human eggs. This work has important implications for human health because aneuploidy in eggs is a leading cause of pregnancy loss, birth defects and infertility.
Keywords: Meiosis / oocyte / actin / spindle / chromosome segregation