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EMBO Associate Member

Michael Rapé

University of California, Berkeley | United States

EMBO 2023

Protein degradation in development and disease

Cell fate specification requires strict control over protein abundance and function. We study mechanisms and regulation of critical ubiquitylation machineries that drive protein degradation and thereby ensure tissue formation and homeostasis during development and upon stress. By hijacking these pathways with small molecules, we also develop targeted protein degradation approaches to correct aberrant protein function in disease.

Keywords: Ubiquitin / protein degradation / ubiquitin code / protein quality control / reductive stress / molecular glues / drug discovery

Subject area(s): Cellular Metabolism | Molecular Medicine | Proteins & Biochemistry | Signal Transduction