
EMBO Member
Michael S. Neuberger
DeceasedEMBO 1989 | CouC 90–95
1953 – 2013
Antibody gene diversification
The research of myself and my colleagues primarily focusses on molecular mechanism of antibody gene diversification (immunoglobulin somatic hypermutaion and class-switch recombination) and extends into the wider contribution of enzyme-catalysed DNA deamination by AID/APOBEC proteins to genome instability and viral restriction. We are also interested in exploiting the antibody iterative maturation process for antibody/protein engineering purposes.