EMBO Member
Michael Sattler
EMBO 2012
Helmholtz-Zentrum München, Garching, Germany
Structure and dynamics of protein-RNA interactions
We employ integrative structural biology combinding NMR, crystallography, cryo-EM, SAXS/SANS and biophysical techniques to study the structure, dynamics and molecular recognition of protein complexes involved in RNA-based regulation of gene expression (alternative splicing, long-non-coding RNAs) and cellular signalling (Hsp90 chaperone and peroxisome biogenesis), and for structure-based drug discovery targing proteins and RNAs.
Keywords
NMR / RNA splicing / alternative splicing / protein-RNA / long non-coding RNAs / integrative structural biology / peroxisome biogenesis / structure-based drug discovery