EMBO Member
Helmholtz-Zentrum München, Garching | Germany
EMBO 2012
We study the structure, dynamics and molecular recognition of protein complexes involved in various aspects of RNA-based regulation of gene expression, i.e (alternative) pre-mRNA splicing, non-coding RNAs (siRNAs, miRNAs). We apply and develop integrated structural biology, combining solution state NMR, small angle X-ray/neutron scattering (SAXS/SANS) experiments and X-ray crystallography with biochemical and biophysical methods.
Keywords: NMR / RNA splicing / alternative splicing / protein-RNA / integrated structural biology / peroxisome biogenesis / structure-based drug discovery
Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics