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EMBO Member

Michael Sattler

Helmholtz-Zentrum M√ľnchen, Garching | Germany

EMBO 2012

Structure and dynamics of protein-RNA interactions

We study the structure, dynamics and molecular recognition of protein complexes involved in various aspects of RNA-based regulation of gene expression, i.e (alternative) pre-mRNA splicing, non-coding RNAs (siRNAs, miRNAs). We apply and develop integrated structural biology, combining solution state NMR, small angle X-ray/neutron scattering (SAXS/SANS) experiments and X-ray crystallography with biochemical and biophysical methods.

Keywords: NMR / RNA splicing / alternative splicing / protein-RNA / integrated structural biology / peroxisome biogenesis / structure-based drug discovery

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics