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EMBO Member

Michael Way

Francis Crick Institute, London | United Kingdom

EMBO 2006 | MemC 09–12

Viral subversion of signalling and cytoskeleton

We use a combination of quantitative imaging and biochemical approaches to study vaccinia virus as a model to interrogate the regulation and function of Src and Rho GTPase signalling networks, actin and microtubule-based transport as well as cell migration. We also examine the mechanisms regulating the assembly and function of invadopodia as well as the cellular function of Tes, a tumour suppressor that regulates Mena-dependent cell migration.

Keywords: Cytoskeletal dynamics / signalling / actin / cell motility / microtubule-based transport / virus / pathogen

Subject area(s): Cell & Tissue Architecture | Membranes & Transport | Microbiology, Virology & Pathogens