Search    Show all

1 People found

filters applied:


1 / 1

EMBO Member

Miguel A. Del Pozo

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid | Spain

EMBO 2021

Cell mechanoadaption and remodeling mechanisms

My lab aims to understand how cells crosstalk with their environment to determine tissue homeostasis and disease. We combine cell biology, biophysics, systematic molecular profiling and in-vivo disease models. A particular focus are caveolae, mechanosensing nanoinvaginations of the plasma membrane, key to understanding the principles of cell and tissue mechanoadaption, and their role in cardiovascular disease, fibrosis and tumor progression.

Keywords: Mechanobiology / caveolae / extracellular matrix remodeling / integrins / Rho-Rac GTPases / actin / cardiovascular disease / tumor microenvironment

Subject area(s): Cell & Tissue Architecture | Immunology | Membranes & Transport | Molecular Medicine | Signal Transduction