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EMBO Associate Member

Mikiko C. Siomi

University, Tokyo | Japan

EMBO 2018

RNA silencing: small RNA biogenesis & functions

Our lab studies small RNA-mediated gene silencing, or RNA silencing, to understand the underlying mechanisms using Drosophila as a model system. We currently focus on piRNAs, germline-specific small RNAs. The main targets of piRNAs are transposons, whose selfish transposition in the genome causes DNA damage, leading to a failure in gametogenesis and infertility. piRNAs run an arms race with transposons to maintain germline genome integrity.

Keywords: RNA silencing in Drosophila / piRISC-mediated transposon silencing in the gonads / transcriptional & post-transcriptional gene repression / piRNA biogenesis / PIWI proteins

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Molecular Medicine | RNA